Wilber is a Professor and has taught at DePaul since 1997. She received her M.F.A. from The School of the Art Institute and has operated her own graphic design and multidisciplinary art practice for over twenty years. Her multidisciplinary approach embraces print, installation, video, performance and radio. Her work has been exhibited widely including in Chicago, Cleveland, Ann Arbor, London, Estonia, Portugal, Germany, and China. She has received many awards including Illinois Arts Council Fellowships, an American Embassy Travel grant, and a Peabody Award for her work for the national public radio program This American Life. Her short film, Chests, was premiered at the Ann Arbor Film Festival.

Wilber has exhibited at the Chicago Cultural Center, The Hyde Park Arts Center, the Cleveland Performance Art Festival, The Royal College of Art in London, the Von Krahli Theatre (Tallin), Rakvere Museum, Estonia, and had performances on the steps of the Museum of Contemporary Art. Her video short, Chests, was premiered at the Ann Arbor Film Festival in 2005. Writing and photography was seen in Fold: the Reader (NC), and this issue of Fold received a Print Regional Annual Award for 2005. Recent work includes a collaborative project on public space and memory with Heitor Alvelos, School of Fine Arts, General Board, Gomes Teixeira Foundation University of Porto, Portugal, She has received awards from numerous sources including the Illinois Art Council, the United States Embassy, the Richard H. Dreihaus Foundation, and the Peabody Award as a producer for the public radio program, This American Life, hosted by Ira Glass.